Endocrine Abstracts

Recent genome-wide association studies of estimated BMD (eBMD) have now included 426,000 individuals, identifying 518 genome-wide significant loci (301 novel), which explain 20% of the total variance in eBMD. Some of these loci are also strongly associated with risk of fracture in a GWAS meta-analysis of 1.2 million individuals. In this talk, I will discuss functional genomics methods that can use this information to identify proteins strongly enriched for known causal protein...